Insights into the Role of Heme in the Mechanism of Action of Antimalarials

Using cell fractionation and measurement of Fe(III)heme-pyridine, the antimalarial chloroquine (CQ) has been shown to cause a dose-dependent decrease in hemozoin and concomitant increase in toxic “free” heme in cultured Plasmodium falciparum that is directly correlated with parasite survival. Transm...

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Main Authors: Combrinck, Jill M., Mabotha, Tebogo E., Ncokazi, Kanyile K., Ambele, Melvin A., Taylor, Dale, Smith, Peter J., Hoppe, Heinrich C., Egan, Timothy J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548943/
https://ncbi.nlm.nih.gov/pubmed/23043646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300454t
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