Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

TNFα-converting enzyme (TACE) is a membrane-bound proteolytic enzyme with essential roles in the functional regulation of TNFα and epidermal growth factor receptor (EGFR) ligands. Previous studies have demonstrated critical roles for TACE in vivo, including epidermal development, immune response, an...

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Autores principales: Saito, Kenta, Horiuchi, Keisuke, Kimura, Tokuhiro, Mizuno, Sakiko, Yoda, Masaki, Morioka, Hideo, Akiyama, Haruhiko, Threadgill, David, Okada, Yasunori, Toyama, Yoshiaki, Sato, Kazuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548805/
https://ncbi.nlm.nih.gov/pubmed/23349978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054853
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