On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells

BACKGROUND: Glioblastoma multiforme (GBM) is characterized by an aggressive clinical course, therapeutic resistance, and striking molecular heterogeneity. GBM-derived brain tumor stem cells (BTSCs) closely model this molecular heterogeneity and likely have a key role in tumor recurrence and therapeu...

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Bibliographic Details
Main Authors: Stechishin, Owen D., Luchman, H. Artee, Ruan, Yibing, Blough, Michael D., Nguyen, Stephanie A., Kelly, John J., Cairncross, J. Gregory, Weiss, Samuel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548588/
https://ncbi.nlm.nih.gov/pubmed/23262510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos302
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