Functional Mapping of the Lectin Activity Site on the β-Prism Domain of Vibrio cholerae Cytolysin: IMPLICATIONS FOR THE MEMBRANE PORE-FORMATION MECHANISM OF THE TOXIN

Vibrio cholerae cytolysin (VCC) is a prominent member in the family of β-barrel pore-forming toxins. It induces lysis of target eukaryotic cells by forming transmembrane oligomeric β-barrel channels. VCC also exhibits prominent lectin-like activity in interacting with β1-galactosyl-terminated glycoc...

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Bibliographic Details
Main Authors: Rai, Anand Kumar, Paul, Karan, Chattopadhyay, Kausik
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548476/
https://ncbi.nlm.nih.gov/pubmed/23209283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430181
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