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Optimal Drug Cocktail Design: Methods for Targeting Molecular Ensembles and Insights From Theoretical Model Systems

Drug resistance is a significant obstacle in the effective treatment of diseases with rapidly mutating targets, such as AIDS, malaria, and certain forms of cancer. Such targets are remarkably efficient at exploring the space of functional mutants and at evolving to evade drug binding while still mai...

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Detaylı Bibliyografya
Asıl Yazarlar: Radhakrishnan, Mala L., Tidor, Bruce
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548403/
https://ncbi.nlm.nih.gov/pubmed/18505239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci700452r
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