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Optimal Drug Cocktail Design: Methods for Targeting Molecular Ensembles and Insights From Theoretical Model Systems
Drug resistance is a significant obstacle in the effective treatment of diseases with rapidly mutating targets, such as AIDS, malaria, and certain forms of cancer. Such targets are remarkably efficient at exploring the space of functional mutants and at evolving to evade drug binding while still mai...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548403/ https://ncbi.nlm.nih.gov/pubmed/18505239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci700452r |
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