The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction

Cells continuously sense and respond to external mechanical forces through their cytoskeleton. Here we show that only a small subset of actin fibers, those forming the perinuclear actin cap that wraps around the nucleus, form in response to low physiological mechanical stresses in adherent fibroblas...

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Main Authors: Chambliss, Allison B., Khatau, Shyam B., Erdenberger, Nicholas, Robinson, D. Kyle, Hodzic, Didier, Longmore, Gregory D., Wirtz, Denis
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548190/
https://ncbi.nlm.nih.gov/pubmed/23336069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01087
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