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Osteoblast Lineage-Specific Effects of Notch Activation in the Skeleton
Transgenic overexpression of the Notch1 intracellular domain inhibits osteoblast differentiation and causes osteopenia, and inactivation of Notch1 and Notch2 increases bone volume transiently and induces osteoblastic differentiation. However, the biology of Notch is cell-context-dependent, and conse...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Endocrine Society
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548181/ https://ncbi.nlm.nih.gov/pubmed/23275471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1732 |
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