Therapeutic effect of CTLA4-Ig on a murine model of primary biliary cirrhosis

Collectively, the data in both humans and murine models of human primary biliary cirrhosis (PBC) suggest that activated T cells, particularly CD8 T cells, play a critical role in biliary cell destruction. Under physiological conditions, T cell activation involves two critical signals that involve th...

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Autori principali: Dhirapong, Amy, Yang, Guo-Xiang, Nadler, Steven, Zhang, Weici, Tsuneyama, Koichi, Leung, Patrick, Knechtle, Stuart, Ansari, Aftab A., Coppel, Ross L., Liu, Fu-Tong, He, Xiao-Song, Gershwin, M. Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548049/
https://ncbi.nlm.nih.gov/pubmed/22996325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26067
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