Effects of Ligand Binding on the Mechanical Properties of Ankyrin Repeat Protein Gankyrin

Ankyrin repeat proteins are elastic materials that unfold and refold sequentially, repeat by repeat, under force. Herein we use atomistic molecular dynamics to compare the mechanical properties of the 7-ankyrin-repeat oncoprotein Gankyrin in isolation and in complex with its binding partner S6-C. We...

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Bibliografiske detaljer
Main Authors: Settanni, Giovanni, Serquera, David, Marszalek, Piotr E., Paci, Emanuele, Itzhaki, Laura S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547791/
https://ncbi.nlm.nih.gov/pubmed/23341763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002864
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