Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer’s disease mice model

BACKGROUND: Alzheimer’s disease (AD) is pathologically characterized by excessive accumulation of amyloid-beta (Aβ) fibrils within the brain and activation of astrocytes and microglial cells. In this study, we examined anti-inflammatory and anti-amyloidogenic effects of 2,4-bis(p-hydroxyphenyl)-2-bu...

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Bibliographic Details
Main Authors: Jin, Peng, Kim, Jin-A, Choi, Dong-Young, Lee, Young-Jung, Jung, Heon Sang, Hong, Jin Tae
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547726/
https://ncbi.nlm.nih.gov/pubmed/23289709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-2
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