Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells

BACKGROUND: Amyloidogenesis is linked to neuroinflammation. The tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal, possesses anti-inflammatory properties in cultured macrophages, and in an arthritis animal model. Because astrocytes and microglia are responsible for amyl...

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Main Authors: Lee, Young-Jung, Choi, Dong-Young, Choi, Im Seup, Han, Jin-Yi, Jeong, Heon-Sang, Han, Sang Bae, Oh, Ki-Wan, Hong, Jin Tae
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207974/
https://ncbi.nlm.nih.gov/pubmed/21982455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-132
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