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The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

We have evaluated two synthetic epothilone analogues lacking the 12,13-epoxide functionality, 12,13-desoxyepothilone B (dEpoB), and 12,13-desoxyepothilone F (dEpoF). The concentrations required for 50% growth inhibition (IC(50)) for a variety of anticancer agents were measured in CCRF-CEM/VBL1000 ce...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Chou, Ting-Chao, O'Connor, Owen A., Tong, William P., Guan, Yongbiao, Zhang, Zui-Guo, Stachel, Shawn J., Lee, Chulbom, Danishefsky, Samuel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35476/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11438750/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131153098
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