Extensive Rigid Analogue Design Maps the Binding Conformation of Potent N-Benzylphenethylamine 5-HT(2A) Serotonin Receptor Agonist Ligands

[Image: see text] Based on the structure of the superpotent 5-HT(2A) agonist 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine, which consists of a ring-substituted phenethylamine skeleton modified with an N-benzyl group, we designed and synthesized a small library of constrained...

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Autors principals: Juncosa, Jose I., Hansen, Martin, Bonner, Lisa A., Cueva, Juan Pablo, Maglathlin, Rebecca, McCorvy, John D., Marona-Lewicka, Danuta, Lill, Markus A., Nichols, David E.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547484/
https://ncbi.nlm.nih.gov/pubmed/23336049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3000668
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