Chronic SSRI Treatment Exacerbates Serotonin Deficiency in Humanized Tph2 Mutant Mice

[Image: see text] Selective serotonin reuptake inhibitors (SSRIs) are a major class of antidepressants that act by blocking inward transport of serotonin (5-HT) into presynaptic neurons mediated by the serotonin transporter (SERT). Both reuptake and ongoing synthesis are essential in supporting intr...

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Main Authors: Siesser, William B., Sachs, Benjamin D., Ramsey, Amy J., Sotnikova, Tatyana D., Beaulieu, Jean-Martin, Zhang, Xiaodong, Caron, Marc G., Gainetdinov, Raul R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2012
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547473/
https://ncbi.nlm.nih.gov/pubmed/23336047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300127h
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