Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice

Probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-HT, serotonin) deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly been reported in depression patients. However, whether such anomalies in fact reflect deficient central 5-HT neurotran...

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Autori principali: Jacobsen, JPR, Siesser, WB, Sachs, BD, Peterson, S, Cools, MJ, Setola, V, Folgering, JHA, Flik, G, Caron, MG
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536482/
https://ncbi.nlm.nih.gov/pubmed/21537332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2011.50
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