High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity

Dihydropyrimidine dehydrogenase (DPD) deficiency is a pharmacogenetic syndrome associated with life-threatening toxicity following exposure to the fluoropyrimidine drugs 5-fluorouracil (5-FU) and capecitabine (CAP), widely used for the treatment of colorectal cancer and other solid tumors. The most...

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Detalhes bibliográficos
Main Authors: Borràs, Emma, Dotor, Emma, Arcusa, Àngels, Gamundi, Maria J., Hernan, Imma, de Sousa Dias, Miguel, Mañé, Begoña, Agúndez, José A. G., Blanca, Miguel, Carballo, Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547229/
https://ncbi.nlm.nih.gov/pubmed/23335937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00312
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