Disrupted-In-Schizophrenia-1 Gln31Leu Polymorphism Results in Social Anhedonia Associated with Monoaminergic Imbalance and Reduction of CREB and β-arrestin-1,2 in the Nucleus Accumbens in a Mouse Model of Depression

Disrupted-in-schizophrenia-1 (DISC1) is associated with mental disorders, including major depression. We previously showed that DISC1-Q31L mutant mice have depression-like behaviors and can therefore be used to study neurobiological mechanisms of depression and antidepressant (AD) medication action....

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Autors principals: Lipina, Tatiana V, Fletcher, Paul J, Lee, Frankie H, Wong, Albert HC, Roder, John C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547193/
https://ncbi.nlm.nih.gov/pubmed/23011268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.197
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