Expansion on Stromal Cells Preserves the Undifferentiated State of Human Hematopoietic Stem Cells Despite Compromised Reconstitution Ability

Lack of HLA-matched hematopoietic stem cells (HSC) limits the number of patients with life-threatening blood disorders that can be treated by HSC transplantation. So far, insufficient understanding of the regulatory mechanisms governing human HSC has precluded the development of effective protocols...

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Autori principali: Magnusson, Mattias, Sierra, Maria I., Sasidharan, Rajkumar, Prashad, Sacha L., Romero, Melissa, Saarikoski, Pamela, Van Handel, Ben, Huang, Andy, Li, Xinmin, Mikkola, Hanna K. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547050/
https://ncbi.nlm.nih.gov/pubmed/23342037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053912
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