GLP-1 secretion by microglial cells and decreased CNS expression in obesity

BACKGROUND: Type 2 diabetes (T2D) is a strong risk factor for developing neurodegenerative pathologies. T2D patients have a deficiency in the intestinal incretin hormone GLP-1, which has been shown to exert neuroprotective and anti-inflammatory properties in the brain. METHODS: Here we investigate p...

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Detalhes bibliográficos
Main Authors: Kappe, Camilla, Tracy, Linda M, Patrone, Cesare, Iverfeldt, Kerstin, Sjöholm, Åke
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546916/
https://ncbi.nlm.nih.gov/pubmed/23259618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-276
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