An analysis and validation pipeline for large-scale RNAi-based screens

Large-scale RNAi-based screens are a major technology, but require adequate prioritization and validation of candidate genes from the primary screen. In this work, we performed a large-scale pooled shRNA screen in mouse embryonic stem cells (ESCs) to discover genes associated with oxidative stress r...

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Autori principali: Plank, Michael, Hu, Guang, Silva, A. Sofia, Wood, Shona H., Hesketh, Emily E., Janssens, Georges, Macedo, André, de Magalhães, João Pedro, Church, George M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546318/
https://ncbi.nlm.nih.gov/pubmed/23326633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01076
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