Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth

BACKGROUND: Constitutive activation of Ras in immortalized bronchial epithelial cells increases electron transport chain activity, oxygen consumption and tricarboxylic acid cycling through unknown mechanisms. We hypothesized that members of the Ras family may stimulate respiration by enhancing the e...

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Bibliographische Detailangaben
Hauptverfasser: Telang, Sucheta, Nelson, Kristin K, Siow, Deanna L, Yalcin, Abdullah, Thornburg, Joshua M, Imbert-Fernandez, Yoannis, Klarer, Alden C, Farghaly, Hanan, Clem, Brian F, Eaton, John W, Chesney, Jason
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546037/
https://ncbi.nlm.nih.gov/pubmed/22917272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-60
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