PKCθ/β and CYLD Are Antagonistic Partners in the NFκB and NFAT Transactivation Pathways in Primary Mouse CD3(+) T Lymphocytes

In T cells PKCθ mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKCθ regulates NFκB transactivation by examining PKCθ/β single and double knockout mice and observed a redundant involvement of PKCθ and PKCβ in this sign...

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Main Authors: Thuille, Nikolaus, Wachowicz, Katarzyna, Hermann-Kleiter, Natascha, Kaminski, Sandra, Fresser, Friedrich, Lutz-Nicoladoni, Christina, Leitges, Michael, Thome, Margot, Massoumi, Ramin, Baier, Gottfried
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546006/
https://ncbi.nlm.nih.gov/pubmed/23335970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053709
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