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The structure of Human Microplasmin in Complex with Textilinin-1, an Aprotinin-like Inhibitor from the Australian Brown Snake

Textilinin-1 is a Kunitz-type serine protease inhibitor from Australian brown snake venom. Its ability to potently and specifically inhibit human plasmin (K(i) = 0.44 nM) makes it a potential therapeutic drug as a systemic anti-bleeding agent. The crystal structures of the human microplasmin-textili...

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Detalhes bibliográficos
Main Authors: Millers, Emma-Karin I., Johnson, Lambro A., Birrell, Geoff W., Masci, Paul P., Lavin, Martin F., de Jersey, John, Guddat, Luke W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545990/
https://ncbi.nlm.nih.gov/pubmed/23335990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054104
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