Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis

BACKGROUND: Anti-viral CD8 T-cell activity is enhanced and prolonged by CD4 T-cell-mediated help, but negatively regulated by inhibitory B7-H1 interactions. During viral encephalomyelitis, the absence of CD4 T cells decreases CD8 T cell activity and impedes viral control in the central nervous syste...

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Main Authors: Phares, Timothy W, Stohlman, Stephen A, Hinton, David R, Bergmann, Cornelia C
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545890/
https://ncbi.nlm.nih.gov/pubmed/23237504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-269
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