The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

BACKGROUND: Changes in glutamatergic neurotransmission via decreased glutamate transporter (GLT) activity or expression contributes to multiple neurological disorders. Chemokines and their receptors are involved in neurological diseases but the role of chemokines in the expression of glutamate trans...

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Autores principales: Fang, Jie, Han, Deping, Hong, Jinsheng, Tan, Qi, Tian, Yeping
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545864/
https://ncbi.nlm.nih.gov/pubmed/23234294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-267
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