Identification of inhibitory scFv antibodies targeting fibroblast activation protein utilizing phage display functional screens

Fibroblast activation protein (FAP) is a serine protease selectively expressed on tumor stromal fibroblasts in epithelial carcinomas and is important in cancer growth, adhesion, and metastases. As FAP enzymatic activity is a potent therapeutic target, we aimed to identify inhibitory antibodies. Usin...

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Bibliographic Details
Main Authors: Zhang, Jiping, Valianou, Matthildi, Simmons, Heidi, Robinson, Matthew K., Lee, Hyung-Ok, Mullins, Stefanie R., Marasco, Wayne A., Adams, Gregory P., Weiner, Louis M., Cheng, Jonathan D.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2013
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545529/
https://ncbi.nlm.nih.gov/pubmed/23104982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-210377
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