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Triplex technology in studies of DNA damage, DNA repair, and mutagenesis

Triplex-forming oligonucleotides (TFOs) can bind to the major groove of homopurine-homopyrimidine stretches of double-stranded DNA in a sequence-specific manner through Hoogsteen hydrogen bonding to form DNA triplexes. TFOs by themselves or conjugated to reactive molecules can be used to direct sequ...

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Autors principals: Mukherjee, Anirban, Vasquez, Karen M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545518/
https://ncbi.nlm.nih.gov/pubmed/21501652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2011.04.001
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