MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila

The abundance of Myc protein must be exquisitely controlled to avoid growth abnormalities caused by too much or too little Myc. An intriguing mode of regulation exists in which Myc protein itself leads to reduction in its abundance. We show here that dMyc binds to the miR-308 locus and increases its...

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Bibliographic Details
Main Authors: Daneshvar, Kaveh, Nath, Sritama, Khan, Abid, Shover, Wesley, Richardson, Christine, Goodliffe, Julie M.
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545263/
https://ncbi.nlm.nih.gov/pubmed/23336071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20122725
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