MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila

The abundance of Myc protein must be exquisitely controlled to avoid growth abnormalities caused by too much or too little Myc. An intriguing mode of regulation exists in which Myc protein itself leads to reduction in its abundance. We show here that dMyc binds to the miR-308 locus and increases its...

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Autors principals: Daneshvar, Kaveh, Nath, Sritama, Khan, Abid, Shover, Wesley, Richardson, Christine, Goodliffe, Julie M.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545263/
https://ncbi.nlm.nih.gov/pubmed/23336071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20122725
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