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Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus

Cholinergic neurons in the laterodorsal tegmental (LDT) and peduncolopontine tegmental (PPT) nuclei regulate reward, arousal, and sensory gating via major projections to midbrain dopamine regions, the thalamus, and pontine targets. Muscarinic acetylcholine receptors (mAChRs) on LDT neurons produce a...

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Hlavní autoři: Kohlmeier, Kristi A., Ishibashi, Masaru, Wess, Jürgen, Bickford, Martha E., Leonard, Christopher S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545116/
https://ncbi.nlm.nih.gov/pubmed/22956788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.01120.2011
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