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‘Transient’ Genetic Suppression Facilitates Generation of Hexose Transporter Null Mutants in Leishmania mexicana

The genome of Leishmania mexicana encompasses a cluster of three glucose transporter genes designated LmxGT1, LmxGT2, and LmxGT3. Functional and genetic studies of a cluster null mutant (Δlmxgt1-3) have dissected the roles of these proteins in Leishmania metabolism and virulence. However, null mutan...

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Détails bibliographiques
Auteurs principaux: Feng, Xiuhong, Rodriguez-Contreras, Dayana, Polley, Tamsen, Lye, Lon-Fye, Scott, David, Burchmore, Richard J.S., Beverley, Stephen M., Landfear, Scott M.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545093/
https://ncbi.nlm.nih.gov/pubmed/23170981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12106
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