MICE EXPRESSING THE ADNFLE VALINE 287 LEUCINE MUTATION OF THE β2 NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT DISPLAY INCREASED SENSITIVITY TO ACUTE NICOTINE ADMINISTRATION AND ALTERED PRESYNAPTIC NICOTINIC RECEPTOR FUNCTION

Several mutations in α4 or β2 nicotinic receptor subunits are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). One such missense mutation in the gene encoding the β2 neuronal nicotinic acetylcholine receptor (nAChR) subunit (CHRNB2) is a valine-to-leucine substitution in the se...

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Main Authors: O’Neill, Heidi C., Laverty, Duncan C., Patzlaff, Natalie E., Cohen, Bruce N., Fonck, Carlos, McKinney, Sheri, McIntosh, J. Michael, Lindstrom, Jon M., Lester, Henry A., Grady, Sharon R., Marks, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544981/
https://ncbi.nlm.nih.gov/pubmed/23123803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2012.10.014
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