Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

TNFα-converting enzyme (TACE/ADAM17) is a membrane-bound proteolytic enzyme with a diverse set of target molecules. Most importantly, TACE is indispensable for the release and activation of pro-TNFα and the ligands for epidermal growth factor receptor in vivo. Previous studies suggested that the ove...

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Autors principals: Yoda, Masaki, Kimura, Tokuhiro, Tohmonda, Takahide, Morioka, Hideo, Matsumoto, Morio, Okada, Yasunori, Toyama, Yoshiaki, Horiuchi, Keisuke
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544834/
https://ncbi.nlm.nih.gov/pubmed/23342154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054412
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