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Microsatellite Instability in the Peripheral Blood Leukocytes of HNPCC Patients
Most hereditary nonpolyposis colorectal cancer (HNPCC) patients inherit a defective allele of a mismatch repair (MMR) gene, usually MLH1 or MSH2, resulting in high levels of microsatellite instability (MSIH) in the tumors. Presence of MSI in the normal tissues of mutation carriers has been controver...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3544178/ https://ncbi.nlm.nih.gov/pubmed/20052760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21190 |
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