Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

In genome-wide association studies (GWAS) of complex traits, single SNP analysis is still the most applied approach. However, the identified SNPs have small effects and provide limited biological insight. A more appropriate approach to interpret GWAS data of complex traits is to analyze the combined...

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Autori principali: Deelen, Joris, Uh, Hae-Won, Monajemi, Ramin, van Heemst, Diana, Thijssen, Peter E., Böhringer, Stefan, van den Akker, Erik B., de Craen, Anton J. M., Rivadeneira, Fernando, Uitterlinden, André G., Westendorp, Rudi G. J., Goeman, Jelle J., Slagboom, P. Eline, Houwing-Duistermaat, Jeanine J., Beekman, Marian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543749/
https://ncbi.nlm.nih.gov/pubmed/22113349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-011-9340-3
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