Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways

Creosote bush-derived nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, possesses antioxidant properties and functions as a potent antihyperlipidemic agent in rodent models. Here, we examined the effect of chronic NDGA treatment of ob/ob mice on plasma dyslipidemia, hepatic steatosis, and...

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Detalhes bibliográficos
Main Authors: Zhang, Haiyan, Shen, Wen-Jun, Cortez, Yuan, Kraemer, Fredric B., Azhar, Salman
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543637/
https://ncbi.nlm.nih.gov/pubmed/23104557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00328.2012
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