Pentoxifylline Attenuates Transforming Growth Factor-β1-Stimulated Collagen Deposition and Elastogenesis in Human Tunica Albuginea-Derived Fibroblasts Part 1: Impact on Extracellular Matrix

INTRODUCTION: Transforming growth factor-β1 (TGF-β1) has been implicated in the pathogenesis of Peyronie’s disease (PD) and also plays a role in collagen and elastin metabolism. Pentoxifylline (PTX) antagonizes the effects of TGF-β1 and has been utilized in our clinic for the management of PD. AIM:...

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Hauptverfasser: Shindel, Alan W., Lin, Guiting, Ning, Hongxiu, Banie, Lia, Huang, Yun-Ching, Liu, Gang, Lin, Ching-Shwun, Lue, Tom F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543151/
https://ncbi.nlm.nih.gov/pubmed/20367772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1743-6109.2010.01790.x
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