XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation

Sustained activation of X-box-binding protein 1 (XBP1) results in endothelial cell (EC) apoptosis and atherosclerosis development. The present study provides evidence that XBP1 mRNA splicing triggered an autophagic response in ECs by inducing autophagic vesicle formation and markers of autophagy BEC...

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Autors principals: Margariti, Andriana, Li, Hongling, Chen, Ting, Martin, Daniel, Vizcay-Barrena, Gema, Alam, Saydul, Karamariti, Eirini, Xiao, Qingzhong, Zampetaki, Anna, Zhang, Zhongyi, Wang, Wen, Jiang, Zhixin, Gao, Chan, Ma, Benyu, Chen, Ye-Guang, Cockerill, Gillian, Hu, Yanhua, Xu, Qingbo, Zeng, Lingfang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543035/
https://ncbi.nlm.nih.gov/pubmed/23184933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.412783
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