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Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling
TGF-β signaling is required for normal tissue repair; however, excessive TGF-β signaling can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF-β binds to cell-surface receptors, resulting in the phosphorylation of the Smad family of transcription factors to...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3543026/ https://ncbi.nlm.nih.gov/pubmed/23204521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431973 |
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