Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling

TGF-β signaling is required for normal tissue repair; however, excessive TGF-β signaling can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF-β binds to cell-surface receptors, resulting in the phosphorylation of the Smad family of transcription factors to...

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Bibliographic Details
Main Authors: Jain, Manu, Rivera, Stephanie, Monclus, Elena A., Synenki, Lauren, Zirk, Aaron, Eisenbart, James, Feghali-Bostwick, Carol, Mutlu, Gokhan M., Budinger, G. R. Scott, Chandel, Navdeep S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543026/
https://ncbi.nlm.nih.gov/pubmed/23204521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431973
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