Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival Mitophagy versus Apoptosis

BH3-only proteins integrate apoptosis and autophagy pathways, yet regulation and functional consequences of pathway cross-talk are not fully resolved. The BH3-only protein Bnip3 is an autophagy receptor that signals autophagic degradation of mitochondria (mitophagy) via interaction of its LC3-intera...

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Bibliographic Details
Main Authors: Zhu, Yanyan, Massen, Stefan, Terenzio, Marco, Lang, Verena, Chen-Lindner, Silu, Eils, Roland, Novak, Ivana, Dikic, Ivan, Hamacher-Brady, Anne, Brady, Nathan R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542995/
https://ncbi.nlm.nih.gov/pubmed/23209295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399345
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