Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test the hypothesis that inhibition of ATR (ATM-Rad3-related) could increase the sensitivity of the cancer cells to radiat...

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Bibliographische Detailangaben
Hauptverfasser: Fokas, E, Prevo, R, Pollard, J R, Reaper, P M, Charlton, P A, Cornelissen, B, Vallis, K A, Hammond, E M, Olcina, M M, Gillies McKenna, W, Muschel, R J, Brunner, T B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542617/
https://ncbi.nlm.nih.gov/pubmed/23222511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.181
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