Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test the hypothesis that inhibition of ATR (ATM-Rad3-related) could increase the sensitivity of the cancer cells to radiat...

詳細記述

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書誌詳細
主要な著者: Fokas, E, Prevo, R, Pollard, J R, Reaper, P M, Charlton, P A, Cornelissen, B, Vallis, K A, Hammond, E M, Olcina, M M, Gillies McKenna, W, Muschel, R J, Brunner, T B
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542617/
https://ncbi.nlm.nih.gov/pubmed/23222511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.181
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