Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test the hypothesis that inhibition of ATR (ATM-Rad3-related) could increase the sensitivity of the cancer cells to radiat...

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Bibliografski detalji
Glavni autori: Fokas, E, Prevo, R, Pollard, J R, Reaper, P M, Charlton, P A, Cornelissen, B, Vallis, K A, Hammond, E M, Olcina, M M, Gillies McKenna, W, Muschel, R J, Brunner, T B
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542617/
https://ncbi.nlm.nih.gov/pubmed/23222511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.181
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