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Cooperative Assembly of Co-Smad4 MH1 with R-Smad1/3 MH1 on DNA: A Molecular Dynamics Simulation Study

BACKGROUND: Smads, the homologs of Sma and MAD proteins, play a key role in gene expression regulation in the transforming growth factor-β (TGF-β) signaling pathway. Recent experimental studies have revealed that Smad4/R-Smad heterodimers bound on DNA are energetically more favorable than homodimeri...

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Detalhes bibliográficos
Main Authors: Wang, Guihong, Li, Chaoqun, Wang, Yan, Chen, Guangju
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542330/
https://ncbi.nlm.nih.gov/pubmed/23326519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053841
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