Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

BACKGROUND: Cyclic GMP (cGMP) signaling attenuates cardiac remodeling, but it is unclear which cGMP effectors mediate these effects and thus might serve as novel therapeutic targets. Therefore, we tested whether the cGMP downstream effector, cGMP-dependent protein kinase G Iα (PKGIα), attenuates pre...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Blanton, Robert M., Takimoto, Eiki, Lane, Angela M., Aronovitz, Mark, Piotrowski, Robert, Karas, Richard H., Kass, David A., Mendelsohn, Michael E.
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2012
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541610/
https://ncbi.nlm.nih.gov/pubmed/23316302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.003731
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