Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates

BACKGROUND: Aggregation of soluble, monomeric β- amyloid (Aβ) to oligomeric and then insoluble fibrillar Aβ is a key pathogenic feature in development of Alzheimer’s disease (AD). Increasing evidence suggests that toxicity is linked to diffusible Aβ oligomers, rather than to insoluble fibrils. The u...

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Detalhes bibliográficos
Main Authors: Sharoar, Md Golam, Thapa, Arjun, Shahnawaz, Mohammad, Ramasamy, Vijay Sankar, Woo, Eun-Rhan, Shin, Song Yub, Park, Il-Seon
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541263/
https://ncbi.nlm.nih.gov/pubmed/23259691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-19-104
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