Functional Characterization of a Chimeric Soluble Fas Ligand Polymer with In Vivo Anti-Tumor Activity

Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras by fusing FasL to domains of the Leukemia Inh...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Daburon, Sophie, Devaud, Christel, Costet, Pierre, Morello, Aurore, Garrigue-Antar, Laure, Maillasson, Mike, Hargous, Nathalie, Lapaillerie, Delphine, Bonneu, Marc, Dechanet-Merville, Julie, Legembre, Patrick, Capone, Myriam, Moreau, Jean-François, Taupin, Jean-Luc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541234/
https://ncbi.nlm.nih.gov/pubmed/23326557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054000
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados