Functional Characterization of a Chimeric Soluble Fas Ligand Polymer with In Vivo Anti-Tumor Activity

Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras by fusing FasL to domains of the Leukemia Inh...

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Hauptverfasser: Daburon, Sophie, Devaud, Christel, Costet, Pierre, Morello, Aurore, Garrigue-Antar, Laure, Maillasson, Mike, Hargous, Nathalie, Lapaillerie, Delphine, Bonneu, Marc, Dechanet-Merville, Julie, Legembre, Patrick, Capone, Myriam, Moreau, Jean-François, Taupin, Jean-Luc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541234/
https://ncbi.nlm.nih.gov/pubmed/23326557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054000
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