Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment

Fas triggers apoptosis via the caspase cascade when bound to its ligand FasL. In type I cells, Fas is concentrated into the plasma membrane lipid rafts, and these domains are required for the apoptotic signal to occur. In contrast, Fas is excluded from the microdomains in type II cells. We report th...

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Bibliografske podrobnosti
Main Authors: Legembre, Patrick, Daburon, Sophie, Moreau, Patrick, Ichas, François, de Giorgi, Francesca, Moreau, Jean-François, Taupin, Jean-Luc
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190328/
https://ncbi.nlm.nih.gov/pubmed/16024813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6811-6820.2005
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