Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment

Fas triggers apoptosis via the caspase cascade when bound to its ligand FasL. In type I cells, Fas is concentrated into the plasma membrane lipid rafts, and these domains are required for the apoptotic signal to occur. In contrast, Fas is excluded from the microdomains in type II cells. We report th...

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Detalhes bibliográficos
Main Authors: Legembre, Patrick, Daburon, Sophie, Moreau, Patrick, Ichas, François, de Giorgi, Francesca, Moreau, Jean-François, Taupin, Jean-Luc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190328/
https://ncbi.nlm.nih.gov/pubmed/16024813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6811-6820.2005
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