In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A

BACKGROUND: The use of food-grade Lactic Acid Bacteria (LAB) as DNA delivery vehicles represents an attractive strategy to deliver DNA vaccines at the mucosal surfaces as they are generally regarded as safe (GRAS). We previously showed that either native Lactococcus lactis (LL) or recombinant invasi...

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Bibliographic Details
Main Authors: de Azevedo, Marcela, Karczewski, Jurgen, Lefévre, François, Azevedo, Vasco, Miyoshi, Anderson, Wells, Jerry M, Langella, Philippe, Chatel, Jean-Marc
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541092/
https://ncbi.nlm.nih.gov/pubmed/23253484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-12-299
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