Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon

Previous studies have shown that human prostate cancer cells constitutively generate 5-lipoxygenase (5-LOX) metabolites from arachidonic acid, and inhibition of 5-LOX blocks production of 5-LOX metabolites and triggers apoptosis in prostate cancer cells. This apoptosis is prevented by exogenous meta...

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Hauptverfasser: Sarveswaran, Sivalokanathan, Thamilselvan, Vijayalakshmi, Brodie, Chaya, Ghosh, Jagadananda
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541030/
https://ncbi.nlm.nih.gov/pubmed/21824498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2011.07.015
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