Successful Use of mRNA-Nucleofection for Overexpression of Interleukin-10 in Murine Monocytes/Macrophages for Anti-inflammatory Therapy in a Murine Model of Autoimmune Myocarditis

BACKGROUND: Overexpression of interleukin-10 (IL-10) in murine CD11b(+) monocytes/macrophages via GMP-adapted mRNA-nucleofection was expected to improve clinical outcome and reduce adverse side effects in autoimmune myocarditis. This study represents the proof of principle for a novel anti-inflammat...

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Bibliografiske detaljer
Main Authors: Zimmermann, Oliver, Homann, Jörg M, Bangert, Anna, Müller, Anna-Maria, Hristov, Georgi, Goeser, Stefan, Wiehe, Juliane M., Zittrich, Stefan, Rottbauer, Wolfgang, Torzewski, Jan, Pfitzer, Gabriele, Katus, Hugo A., Kaya, Ziya
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2012
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540678/
https://ncbi.nlm.nih.gov/pubmed/23316321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.003293
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